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).eighty two,eighty three Sufferers with MBL with mutated drivers Possess a shorter time for you to initial therapy in comparison to instances without mutations. Once CLL is established, The expansion dynamics of tumor cells is heterogeneous. Some sufferers exhibit a logistic-like actions wherein the clone stabilizes after some time, While some Other people show an exponential- like advancement sample.84 This exponential advancement, clinically outlined as “quick lymphocyte doubling time” remains to be regarded as an adverse prognostic parameter in CLL.
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